Nanoscale Dynamics of Amyloid β-42 Oligomers As Revealed by High-Speed Atomic Force Microscopy
نویسندگان
چکیده
منابع مشابه
High-speed atomic force microscopy reveals structural dynamics of amyloid β1-42 aggregates.
Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various neurodegenerative diseases. This process involves protein assembly into oligomeric intermediates and fibrils with highly polymorphic molecular structures. These structural differences may be responsible for different disease presentations. For this reason, elucidation of the structural features and ass...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2017
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.7b05434